In 2025, EHR Software remains an indispensable backbone of modern healthcare delivery. Electronic health record systems not only house patient data but transform how clinicians deliver care, manage workflows, share clinical intelligence, and improve outcomes.
In this article, we examine the 20 top EHR software options currently available, highlighting their key capabilities, ideal use cases, advanced features, and what distinguishes each in this competitive healthcare technology landscape.
Before diving into the EHR reviews, it’s essential to understand why EHR software is crucial in healthcare in 2025.
What Is EHR Software?
EHR Software refers to digital systems that centralize and manage patients’ medical information — including diagnoses, treatment plans, medications, allergies, laboratory results, billing activity, appointment history, clinical notes, and more — in a single digital platform accessible by authorized care teams.
Unlike legacy paper records or basic electronic medical records (EMR), EHRs are engineered to support data exchange and interoperability across organizations, improve clinical decision support workflows, and comply with regulatory standards across regions. PeerSpot
Modern EHR software also incorporates features such as:
- Telehealth and virtual care modules
- AI-augmented documentation and decision support
- Secure, cloud-based access and data sharing
- Practice management and revenue cycle integration
- Mobile clinician access
- Patient portals for self-service
With that foundation, let’s examine the 20 best EHR software systems healthcare organizations should consider in 2025.
20 Best EHR Software for Healthcare Providers (2025)
1. Epic Systems
Epic continues to dominate the global EHR software market, particularly for large hospitals, integrated delivery networks, and academic medical centers. Known for its powerful interoperability, Epic enables seamless health information exchange across care settings and institutions.
Epic’s ecosystem — including MyChart for patients — offers advanced tools for telehealth, analytics, population health, and AI-driven clinical guidance.
Best for: Large hospitals and health systems
Strengths: Interoperability, analytics, deep customization
Limitations: Cost and complexity for smaller practices
2. Oracle Cerner
Cerner, now part of Oracle Health, is one of the most widely deployed enterprise EHR software solutions globally with deep capabilities in clinical, financial, and operational workflows. As a cloud-enabled system, Cerner supports real-time data exchange, AI-enhanced clinical alerts, and scalable deployments across multi-site networks.
Best for: Health systems and multisite practices
Strengths: Integrated revenue cycle, customizable modules
Limitations: Implementation complexity
3. athenahealth
athenahealth is a cloud-native EHR software platform that offers strong ambulatory care workflow support, billing automation, telehealth, and patient engagement tools. It is widely regarded for its ease of use and strong customer support infrastructure, including live onboarding success teams to guide organizations through transitions.
Best for: Small to mid-sized practices
Strengths: Cloud delivery, patient portal, telehealth
Limitations: Pricing transparency
4. NextGen Healthcare
NextGen Healthcare’s platform blends EHR with practice management, patient scheduling, and billing capabilities. It appeals to practices seeking customizable templates and integration with reporting tools. Its mobile access and telemedicine modules enhance clinician productivity.
Best for: Specialty and ambulatory clinics
Strengths: Customizable workflows, patient engagement tools
Limitations: Learning curve
5. eClinicalWorks
eClinicalWorks is known for its comprehensive feature set for ambulatory environments — from secure messaging and lab integration to telehealth and e-prescribing. Unique features such as advanced search and timeline views help clinicians access critical patient history quickly.
Best for: Community care centers and multi-site outpatient groups
Strengths: Telehealth, patient portal, scalable features
Limitations: Practice management tools may require add-ons
6. Allscripts
Allscripts delivers flexible EHR software designed for enterprise and ambulatory settings alike. Its open API and integration capabilities allow providers to connect to third-party analytics and patient engagement tools. While comprehensive, the system sometimes requires strong implementation support teams.
Best for: Medium to large providers
Strengths: Open API and integration ecosystem
Limitations: Longer onboarding period
7. CareCloud
CareCloud’s EHR software emphasizes ease of use and a modern cloud interface. Alongside clinical documentation, scheduling, and billing services, CareCloud includes analytics dashboards and patient engagement tools that help practices streamline operations and grow revenue.
Best for: Ambulatory practices and smaller organizations
Strengths: User experience, staffing insights
Limitations: Less robust than enterprise systems
8. RXNT
RXNT is highlighted in multiple 2025 EHR software rankings as a strong budget-friendly option, offering certified clinical documentation, electronic prescribing, patient intake, scheduling, and referrals. Its simplicity and customization make it ideal for smaller practices.
Best for: Small and independent practices
Strengths: Cost-effective, core features
Limitations: Feature depth vs. larger platforms
9. Practice Fusion
Practice Fusion is a cloud-based EHR software solution tailored for small to medium practices. Its intuitive interface, integrated e-prescribing, lab result management, and patient portal keep patient information organized and accessible.
Best for: Small clinics
Strengths: Affordable, easy implementation
Limitations: Basic compared to enterprise systems
10. Kareo Clinical
Kareo Clinical bridges EHR functionality with practice management and billing for small and independent medical practices. It provides HIPAA-compliant virtual care features and patient portals for secure messaging and payment processing.
Best for: Small practices and solo clinicians
Strengths: Integrated billing and telehealth
Limitations: Scaling to larger enterprises
11. DrChrono
DrChrono stands out with a mobile-friendly EHR software suite that supports iPad and iPhone users. It offers telehealth integration, customizable clinical tools, and strong billing features suited to modern practices that value mobility.
Best for: Practices valuing mobile access
Strengths: Mobile UI, flexibility
Limitations: Custom pricing
12. Praxis EMR
Praxis EMR is distinctive in its use of artificial intelligence to learn from clinician documentation patterns and optimize charting workflows over time. It is especially useful for practices wanting an adaptive and intelligent EHR experience.
Best for: Specialty practices and AI-driven workflows
Strengths: Adaptive intelligence
Limitations: The Learning phase may be lengthy
13. Meditech Expanse
Meditech Expanse provides an all-in-one EHR software solution that supports clinical documentation, prescriptions, patient portals, and revenue cycle management. It is suited to larger practices and health systems focusing on scalable enterprise features.
Best for: Hospitals and large multi-department systems
Strengths: Comprehensive modules
Limitations: Deployment cost
14. OpenEMR
OpenEMR is a free, open-source EHR software platform certified for ambulatory use in many regions. It supports scheduling, billing, clinical documentation, and patient communications — a solid choice for small practices or low-resource environments.
Best for: Resource-constrained practices
Strengths: Open-source and free
Limitations: Requires internal IT support
15. OpenMRS
OpenMRS is an open-source EHR platform geared toward flexibility and customization in diverse healthcare environments. It is particularly well-suited to global health initiatives or resource-limited settings where custom workflows are critical.
Best for: Custom deployments
Strengths: Highly customizable
Limitations: Not turnkey
16. Veradigm EHR
Veradigm EHR is highly rated by clinical users for integrating patient data management with analytics. According to PeerSpot user data, Veradigm ranks among the top EHR solutions in terms of customer satisfaction and overall performance in 2025.
Best for: Practices seeking analytics insights
Strengths: Data visualization tools
Limitations: Adoption curve
17. MediCore Connect
MediCore Connect emphasizes interoperability and population health analysis with advanced dashboards and predictive analytics tools. It is gaining traction among integrated health networks looking to optimize preventive care outcomes.
Best for: Population health-centric organizations
Strengths: Analytics and integration
Limitations: Emerging profile
18. SimplePractice
While often considered in behavioral health and wellness spaces, SimplePractice includes certified EHR software capabilities with scheduling, telehealth, billing, and customizable templates — making it a useful platform for smaller multidisciplinary practices.
Best for: Behavioral health and therapy clinics
Strengths: Affordable and easy to use
Limitations: Less robust in acute care
19. Spry PT
Spry PT is designed for specialty therapy practices and includes tailored EHR features that support documentation, billing, patient intake, and therapy-specific workflows, making it an emerging choice in 2025 EHR software lists.
Best for: Physical and occupational therapy clinics
Strengths: Specialty documentation
Limitations: Less general clinical focus
20. Additional Niche and Specialty EHR Software
Beyond the major systems listed above, numerous specialty and niche EHR software platforms continue to evolve, including oncology-focused systems, dental-oriented EHRs, and AI-augmented documentation tools. Providers should evaluate these based on specific clinical needs, interoperability requirements, and workflow alignment.
How to Choose the Right EHR Software in 2025?
Selecting the best EHR software depends on several factors:
- Practice Size and Setting — Large hospitals need enterprise-grade systems like Epic or Cerner, while smaller practices may thrive with scaled options like RXNT, Practice Fusion, or SimplePractice.
- Feature Needs — Evaluate telehealth, billing, analytics, interoperability, and mobile access based on your workflows.
- Budget — Cloud-based EHR software reduces upfront costs but may involve subscription fees; open-source options minimize licensing expenses.
- Compliance and Security — Ensure the platform meets legal and privacy requirements in your region.
- Training and Support — Strong onboarding and ongoing support can make or break clinician adoption.
FAQs
1. What is the most widely used EHR software in 2025?
Epic Systems continues to lead in market adoption among large health systems and integrated networks, often regarded as the industry standard for comprehensive EHR software in 2025.
2. Can small practices afford advanced EHR software?
Yes. Many cloud-based EHR software platforms like RXNT, Practice Fusion, and SimplePractice offer cost-effective subscription plans designed for small to mid-sized practices.
3. Why is interoperability important in EHR software?
Interoperability allows different EHR systems and care settings to share patient data securely and in real time, which reduces errors, enhances care coordination, and improves clinical outcomes.
